The compounds show a high and selective binding affinity for the histamine H3 receptor, indicating histamine H3 receptor antagonistic, inverse agonistic or agonistic activity. 这些化合物表现出对组胺H3受体的高度和选择性亲和力,从而表现出组胺H3受体的拮抗、反激动剂或激动剂活性。
Purpose: To establish the biophore of prostate selective α 1 adrenoceptor antagonist. Method: Five compounds were selected with high affinity on α 1A AR and prostate. 目的:建立具有尿道选择性α1肾上腺素受体拮抗剂的药效团模型。
After denaturation and renaturation in vitro, the expressed pro UK was purified to Identity by Zn 2+ selective precipitation, immuno affinity chromato graphy, and Benzamidine affinity adsorption. The specific activity of the purified human pro UK was about 110000IU/ mg. 经体外变复性,Zn2+选择性沉淀,抗体亲和柱层析,及Benzamidine亲和吸附,所表达的人尿激酶原被纯化为单一条带,其比活约110000IU/mg。
Methods: α-AI in many kinds of high-starch fruits was purified by selective thermal denaturation, ionic exchange and affinity chromatography, and a study was made on its basic characteristics and content as well. 方法:多种高淀粉植物果实通过选择性热变性、离子交换层析、亲和层析等分离提纯α淀粉酶(EC,3.2.1.1)的抑制剂,并对抑制剂的含量进行分析。
The selective binding experiment for substrates indicated that the polymer gave much higher affinity and selectivity for triadimenol than analogues. 底物选择性实验表明,与其它结构相似的分子相比,该聚合物对三唑醇显示很强的结合能力。
The fluorescent histochemistry test indicted that Gal PLL had a selective affinity to the rat liver tissues. 经荧光组化分析表明,GalPLL对大鼠肝组织有选择性亲和力;
These Au NCs thus show great potential applications in detection and treatment of cancers and other diseases due to their selective affinity to cancer cells, excellent near-infrared emission, high photostability, good biocompatibility and low cytotoxicity. 这种对癌细胞具有选择性、良好的近红外荧光、光稳定性、优良的生物相容性和低毒性使纳米金团簇在造血系统中的癌症和其它疾病的诊断和治疗中有着光明的应用前景。